Mosquitoes Trade Fertility for Immune Defense against Malaria
نویسنده
چکیده
A study of Anopheles gambiae mosquitoes shows that a molecule involved in defense against the malaria parasite also plays a role in male fertility, identifying a potential evolutionary trade-off between immunity and reproductive fitness. Read the Research Article.
منابع مشابه
The Humoral Anti-bacterial Response of Anopheles Gambiae and the Immunity- Reproduction Trade-off: between the Hope and Limitation of the Malaria Immuno-control Strategy
In this study, induction of the humoral anti-bacterial activity of the African human malaria vector, Anopheles gambiae, and the mechanisms of the concomitant fecundity reduction were investigated. The blood meal induced a humoral anti-Micrococcus luteus activity, which was detectable at 12h, peaked around 24h and become hardly detectable at 48h post-feeding. This humoral activity was also detec...
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The employment of defense mechanisms is recognized as a costly life-history trait. In the malaria vector Anopheles gambiae, reproductive costs have been associated with both humoral and cellular innate immune responses and also with malaria infection. The resorption of developing oocytes associated with malaria infection is preceded by the programmed cell death, or apoptosis, of follicular cell...
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Malaria-transmitting mosquitoes are continuously exposed to microbes, including their midgut microbiota. This naturally acquired microbial flora can modulate the mosquito's vectorial capacity by inhibiting the development of Plasmodium and other human pathogens through an unknown mechanism. We have undertaken a comprehensive functional genomic approach to elucidate the molecular interplay betwe...
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The mosquito Anopheles gambiae uses its innate immune system to control bacterial and Plasmodium infection of its midgut tissue. The activation of potent IMD pathway-mediated anti-Plasmodium falciparum defenses is dependent on the presence of the midgut microbiota, which activate this defense system upon parasite infection through a peptidoglycan recognition protein, PGRPLC. We employed transcr...
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Hematophagous vectors strictly require ingesting blood from their hosts to complete their life cycles. Exposure of the alimentary canal of these vectors to the host immune effectors necessitates efficient counteractive measures by hematophagous vectors. The Anopheles mosquito transmitting the malaria parasite is an example of hematophagous vectors that within seconds can ingest human blood doub...
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عنوان ژورنال:
دوره 13 شماره
صفحات -
تاریخ انتشار 2015