Effect of in utero and early-life conditions on adult health and disease.

Fabry dissase from the dentist view

                 Fabry disease is a rare, inherited disease with lack of the enzyme alpha-galactosidase A (α-Gal)  in the cells of the body that participates in the breakdown of fat. The disease begins in early childhood, progresses slowly throughout life and results in severe damage of the kidneys, heart and central nervous system. The disease is life-threatening and if left untreated, death ...

In Utero and Early-Life Conditions and Adult Health and Disease

The Impact of Plasmodium Berghei Exposure In-utero on Neurobehavioral Profile in Mice

Introduction: The World Health Organization estimates that about 25 million pregnant mothers are currently at risk for malaria, and that malaria accounts for over 10,000 maternal and 200,000 neonatal deaths per year. The current hypothesis of early life programming supports the premise that many developmental delay and disorders may have their origin In-utero. Therefore, the current study aimed...

Oral Health-Related Quality of Life: A Cross-Sectional Survey among Adult Patients in Mashhad, Iran

Introduction: Quality of life is defined as the sense of well-being and satisfaction with daily performances influenced by dental and oral conditions. Oral diseases are very common and have impacts on different aspects of individual's life and can change their performances. In other word, they can change the quality of life. The real impact of health and disease on daily performances is conside...

Effect of family-centered empowerment model on quality of life in adults with chronic diseases: A systematic review and meta-analysis study

Background & Aim: Empowerment is a dynamic, positive, interactive and social process, leading to the improvement of quality of life (QOL) in patients with chronic disease. The purpose of this systematic review and meta-analysis was to determine the effect of family-centered empowerment model (FCEM) on QOL in adults with chronic diseases. Methods & Materials: By searching FCEM in Persian databa...

Intrauterine programming

In mammals, the intrauterine condition has an important role in the development of fetal physiological systems in later life. Suboptimal maternal environment can alter the regulatory pathways that determine the normal development of the fetus in utero, which in post-natal life may render the individual more susceptible to cardiovascular or metabolic adult-life diseases. Changes in the intrauter...