Vasorelaxing Action of Vasonatrin Peptide is Associated with Activation of Large-conductance Ca-activated Potassium Channels in Vascular Smooth Muscle Cells Short title: VNP Enhances BKCa in VSMCs
نویسندگان
چکیده
1 Preclinical Experiment Center, Fourth Military Medical University, Xi’an, Shaanxi, China 2 Department of Physiology, Fourth Military Medical University, Xi’an, Shaanxi, China 3 Center of clinical aviation medicine, General Hospital of Air Force, Beijing, China 4 Department of Pharmacology, Fourth Military Medical University, Xi’an, Shaanxi, China 5 Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China
منابع مشابه
Vasorelaxing action of vasonatrin peptide is associated with activation of large-conductance Ca(2+)-activated potassium channels in vascular smooth muscle cells.
The aim of this study was to test the hypothesis that vasorelaxing action of vasonatrin peptide (VNP) is due to activation of the large-conductance Ca(2+)-activated potassium channel (BK(Ca)) via guanylyl cyclase (GC)-coupled natriuretic peptide receptors (NPRs) in vascular smooth muscle cells (VSMCs). Contraction experiments were performed using human radial artery, whereas BK(Ca) current by p...
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