TCDD: The Deadliest Toxic Chemical Known to Science
نویسنده
چکیده
On Saturday July 10, 1976, it was a warm spring day filled with blue skies and normalcy. With children playing outside under the sun-kissed rays and others enjoying lunch outdoors, all were oblivious to one of the biggest man-made chemical disasters that was about to take place. What was a seemingly picturesque afternoon was soon to be history due to the foreboding thick, whitish cloud overhead. The ominous cloud that loomed over Seveso, Italy attracted rapid international media attention and became headlines everywhere during the 1980s. The mysterious cloud was the result of an explosion during the production of trichlorophenol at the chemical plant ICMESA (Industrie Chimiche Meda Società Azionaria). However, it wasn’t necessarily the explosion that kept the public’s attention, but the significant amounts of the highly toxic 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) that the cloud contained.
منابع مشابه
An analytical method for detecting TCDD (dioxin): levels of TCDD in samples from Vietnam.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is an extraordinarily toxic substance that is produced as an unwanted side product in the industrial synthesis of 2,4,5-trichlorophenol, an intermediate in the manufacture of the herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) (1, 2). Because of its chemical stability and its lipophilic nature, the possibility exists that TCDD released into the e...
متن کاملFate and transport of 1278-TCDD, 1378-TCDD, and 1478-TCDD in soil-water systems.
The most toxic dioxin is 2,3,7,8-tetrachlorodibenzo-p-dioxin (2378-TCDD), and obtaining comprehensive experimental data for this compound is challenging. However, several nontoxic isomers of 2378-TCDD exist, and can provide significant experimental evidence about this highly toxic dioxin. The goal of this study was to obtain experimental evidence for the fate and transport of 2378-TCDD in natur...
متن کاملHematologic and clinical chemistry effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in laboratory animals.
Chlorodibenzo-p-dioxins, especially 2,3,7,8tetrachlorodibenzo-p-dioxin (TCDD), are among the most toxic compounds known. These compounds are found as contaminants of technical chlorophenols and their derivatives. A variety of pathologic condition have been associated with the injestion of products containing chlorodibenzo-p-dioxins. Toxic fat, the cause of chick edema disease (1, 2) and a varie...
متن کامل2,3,7,8-Tetrachlorodibenzo-p-dioxin upregulates FoxQ1b in zebrafish jaw primordium.
Vertebrate jaw development can be disrupted by exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-a potent activator of the aryl hydrocarbon receptor (AHR) transcription factor required for transducing the toxic effects of TCDD. We used zebrafish (Danio rerio) embryos to investigate transcriptional responses to TCDD with the goal of discovering novel, jaw-specific genes affected by TCDD exp...
متن کاملPathologic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in laboratory animals.
The technical chlorophenols and products produced from them, such as the herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) have been found to contain chlorodibenzo-pdioxins such as 2,3,7,8-tetrachlorodibenzo-pdioxin (TC-DD). TCDD and other chlorodibenzo-p-dioxins are among the most toxic compounds known, and have been implicated in outbreaks of chloracne among chemical workers (1). Hepatic ...
متن کامل