Quantification of holo-transcobalamin, a marker of vitamin B12 deficiency.
نویسندگان
چکیده
Vitamin B12 Deficiency, Ebba Nexo, 1* Anna-Lisa Christensen, Anne-Mette Hvas, Torben E. Petersen, and Sergey N. Fedosov ( Department of Clinical Biochemistry, Aarhus University Hospital, DK-8000 Aarhus C, Denmark; 2 The Laboratory for Protein Chemistry, University of Aarhus, DK-8000 Aarhus C, Denmark; * address correspondence to this author at: Department of Clinical Biochemistry, AKH, Aarhus University Hospital, Norrebrogade 44, DK-8000 Aarhus C, Denmark; fax 45-8949-3060, e-mail [email protected])
منابع مشابه
Holotranscobalamin (HoloTC, Active-B12) and Herbert’s model for the development of vitamin B12 deficiency: a review and alternative hypothesis
The concentration of total vitamin B12 in serum is not a sufficiently sensitive or specific indicator for the reliable diagnosis of vitamin B12 deficiency. Victor Herbert proposed a model for the staged development of vitamin B12 deficiency, in which holotranscobalamin (HoloTC) is the first indicator of deficiency. Based on this model, a commercial immunoassay has been controversially promoted ...
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Vitamin B12 deficiency is widespread. Among the population groups at risk are older people, vegetarians, pregnant women and patients with renal or intestinal diseases. The neurological symptoms of vitamin B12 deficiency are unspecific and can be irreversible. Early detection is therefore important. This article reviews the diagnostic performance of the different laboratory markers for vitamin B...
متن کاملHolo-Transcobalamin Concentrations and Transcobalamin Saturation Reflect Recent Vitamin B12 Absorption Better than Does Serum Vitamin B12
Background: We evaluated whether measurement of vitamin B12-saturated transcobalamin (holo-TC) concentrations or TC saturation (holo-TC:total TC) reflects active vitamin B12 absorption in healthy individuals and patients after vitamin B12 intake. Methods: We obtained blood samples from 31 healthy individuals (age range, 25–57 years) before (days 1 and 0) and after (days 1, 2, and 6) oral admini...
متن کاملHolotranscobalamin Is a Useful Marker of Vitamin B12 Deficiency in Alcoholics
BACKGROUND Measurement of serum cobalamin (Cbl) levels is the standard investigation for assessing vitamin B12 deficiency. Falsely increased values of Cbl can be caused by alcoholic liver disease. Measurement of total vitamin B12 serum levels might be misleading in alcoholics, because a tissue metabolic deficiency is possible even with normal serum Cbl levels. Holotranscobalamin (HoloTC), the C...
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ورودعنوان ژورنال:
- Clinical chemistry
دوره 48 3 شماره
صفحات -
تاریخ انتشار 2002