Comparison of commercial one-dose and two-dose baculovirus-expressed porcine circovirus type 2 subunit vaccines
نویسنده
چکیده
Porcine circovirus type 2 (PCV2) is a small, non-enveloped, single-stranded DNA virus in the genus Circovirus within the family Circoviridae.1 It has been incriminated as a major causative agent of postweaning multisystemic wasting syndrome (PMWS), which is known as PCV2-associated diseases (PCVAD);2,3 PCVAD is considered to be an economically important global issue. Most Korean swine farms (95.5%) use a PCV2 vaccine for control of PCVAD because the vaccine is highly efficacious.4
منابع مشابه
Comparison of four commercial one-dose porcine circovirus type 2 (PCV2) vaccines administered to pigs challenged with PCV2 and porcine reproductive and respiratory syndrome virus at 17 weeks postvaccination to control porcine respiratory disease complex under Korean field conditions.
Under Korean field conditions, coinfection with porcine circovirus type 2 (PCV2) and porcine reproductive and respiratory syndrome virus (PRRSV) is most commonly observed in porcine respiratory disease complex (PRDC). Despite the wide use of PCV2 vaccination, PRDC remains a serious respiratory problem. Thus, the objective of this study was to determine and compare the efficacy of 4 one-dose PCV...
متن کاملTitle: Head-to-head comparison of the level of protection and duration of immunity induced by different commercial and an autogenous PCV2 vaccine – NPB #07-210 Investigator:
The study objectives were to compare the duration of immunity of commercially available, one and two dose, killed porcine circovirus type 2 (PCV2) vaccines. Sixty, 3.5-week-old pigs were randomly divided into 6 treatment groups: one dose vaccines (FDAH-1, BIVI-1), two dose vaccines (Intervet-2, FDAH-2), and nonvaccinated negative and positive controls. Tissue homogenate challenge was conducted ...
متن کاملOne dose of a porcine circovirus 2 subunit vaccine induces humoral and cell-mediated immunity and protects against porcine circovirus-associated disease under field conditions.
This study investigated the efficacy of a one-dose porcine circovirus 2 (PCV2) subunit vaccine based on the PCV2 Cap protein expressed in a baculovirus system on two different farms at which a history of porcine circovirus-associated disease (PCVD) was present. Morbidity, mortality, average daily weight gain, carcass weight, PCV2 load in serum and vaccine immunogenicity were assessed. Serology ...
متن کاملImproved Production Efficiency of Virus-Like Particles by the Baculovirus Expression Vector System
Vaccines based on virus-like particles (VLPs) have proven effective in humans and animals. In this regard, the baculovirus expression vector system (BEVS) is one of the technologies of choice to generate such highly immunogenic vaccines. The extended use of these vaccines for human and animal populations is constrained because of high production costs, therefore a significant improvement in pro...
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The Cap protein of porcine circovirus type 2 (PCV2) that serves as a major host-protective immunogen was used to develop recombinant vaccines for control of PCV2-associated diseases. Growing research data have demonstrated the high effectiveness of flagellin as an adjuvant for humoral and cellular immune responses. Here, a recombinant protein was designed by fusing a modified version of bacteri...
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