Molecular Subtypes of Clear Cell Renal Cell Carcinoma Are Associated to Sunitinib Response in the Metastatic Setting
نویسندگان
چکیده
BB, AK, GC, JZR: Inserm, UMR-1162, Génomique fonctionnelle des tumeurs solides, IUH, F-75010 Paris, France. BB, EB, AK, VG, GC, NG, MS, AM, WHF, CSF, SO, JZR: Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, F-75006 Paris, France. BB, EB, AK, GC, WHF, CSF, JZR: Labex Immuno-oncology EB, NG, WHF, CSF: UMR_S1138, Centre de Recherche des Cordeliers, F-75006 Paris, SJ, ADR: Programme Cartes d'Identité des Tumeurs, Ligue Nationale Contre le Cancer, F-75013 Paris, France JZR, CT, AM, RE, BB, SO: Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, department of Oncology, F-75015 Paris, France. VV: Assistance Publique-Hôpitaux de Paris, Hôpital Necker-Enfants malades, department of Pathology, F-75015 Paris, France. MS: Assistance Publique-Hôpitaux de Paris, Hôpital Cochin, department of Pathology, F-75014 Paris, France. JJP: Department of Urology, Hôpital Bicêtre, F-94270 Le Kremlin-Bicêtre, France. NRL: Department of Pathology, CHU Rennes, F-35000 Rennes, France VM: Department of Pathology, Clinique St-Joseph, F-75014 Paris, France
منابع مشابه
Molecular subtypes of clear cell renal cell carcinoma are associated with sunitinib response in the metastatic setting.
PURPOSE Selecting patients with metastatic clear-cell renal cell carcinoma (m-ccRCC) who might benefit from treatment with targeted tyrosine kinase inhibitors (TKI) is a challenge. Our aim was to identify molecular markers associated with outcome in patients with m-ccRCC treated with sunitinib. EXPERIMENTAL DESIGN We performed global transcriptome analyses on 53 primary resected ccRCC tumors ...
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