Coexistence of degenerative aortic stenosis and wild type transthyretin-related cardiac amyloidosis: a potentially dangerous association that can be non-invasively identified
نویسندگان
چکیده
Background Degenerative aortic stenosis (AS) and wild type transthyretin (TTR)-related cardiac amyloidosis (wt-ATTR) share a common demographic and clinical profile. It has been recently suggested that the coexistence of wt-ATTR could negatively influence the outcome of elderly patients with aortic stenosis undergoing transcatheter aortic valve replacement (TAVR). TTR-related cardiac amyloidosis can be accurately identified by technetium-99m-3, 3-diphosphono-1, 2 propanodicarboxylic acid (99mTc-DPD) scintigraphy. We decided to investigate the coexistence of cardiac amyloidosis in elderly patients with aortic stenosis referred for aortic valve replacement (TAVR or surgery).
منابع مشابه
Prognostic Significance of Occult Transthyretin Cardiac Amyloidosis in Patients With Severe Aortic Stenosis Undergoing Surgical Aortic Valve Replacement: An Unrecognized Disease Modifier.
Aortic stenosis (AS), a common condition affecting 3% of individuals aged >75 years, leads to heart failure and death unless the valve is replaced. Recently, patients with concomitant degenerative AS and transthyretin-related cardiac amyloidosis have been reported. One prospective study investigated the coexistence of cardiac amyloidosis in elderly patients with AS who were referred for an aort...
متن کاملPrognostic Significance of Occult Transthyretin Cardiac Amyloidosis in Patients With Severe Aortic Stenosis Undergoing Surgical Aortic Valve Replacement
Aortic stenosis (AS), a common condition affecting 3% of individuals aged >75 years, leads to heart failure and death unless the valve is replaced. Recently, patients with concomitant degenerative AS and transthyretin-related cardiac amyloidosis have been reported. One prospective study investigated the coexistence of cardiac amyloidosis in elderly patients with AS who were referred for an aort...
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