Neutropenia Following Intravenous Immunoglobulin Administration in a Patient with Multifocal Motor Neuropathy with Conduction Block
نویسندگان
چکیده
Intravenous immunoglobulin (IVIG) is the treatment of choice in patients with multifocal motor neuropathy with conduction block (MMNCB). Although IVIG is considered generally safe, neutropenia following IVIG infusion has been recognized as a rare hematologic side effect. Herein we report a patient with MMNCB who developed severe neutropenia following IVIG administration. A 41 year old woman presented with progressive weakness of her left lower extremity with frequent muscle cramps. Nerve conduction study revealed marked conduction blocks on right ulnar and right tibial nerves. Serum IgM anti-GM1 antibody was detected. Neutrophil count decreased from day 2 and recovered after 2 weeks following IVIG infusion. To our knowledge, neutropenia following IVIG infusion in MMNCB has never been discussed apart, although it can be an important clinical issue especially for patients with MMNCB.
منابع مشابه
Delayed Appearance of Conduction Block in Multifocal Motor Neuropathy—A Case Report
I ntroduction: Multifocal motor neuropathy (MMN) is a rare, treatable, immune-mediated neuropathy often associated with multifocal conduction block (CB). The hallmark electrodiagnostic feature is the presence of CB occurring at non-entrapment sites. However, MMN without CB has also been described and can be diagnosed, even in the absence of CB. Therefore, it is crucial to diagnose and identify ...
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