Erythromycin may potentially increase the risk of qt prolongation more than azithromycin
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چکیده
Antimicrobials that are associated with QT prolongation include the. Torsades de pointes (TdP), a potentially fatal polymorphic ventricular. . are more susceptible to the effects of these small changes than are others [17, 18].. As a result of increased exposure to an IKr-blocking agent, risk of TdP may increase [ 26, 27].
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Divergent proarrhythmic potential of macrolide antibiotics despite similar QT prolongation: fast phase 3 repolarization prevents early afterdepolarizations and torsade de pointes.
Macrolide antibiotics are known to have a different proarrhythmic potential in the presence of comparable QT prolongation in the surface ECG. Because the extent of QT prolongation has been used as a surrogate marker for cardiotoxicity, we aimed to study the different electrophysiological effects of the macrolide antibiotics erythromycin, clarithromycin, and azithromycin in a previously develope...
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