Total synthesis of ceratopicanol through tandem cycloaddition reaction of a linear substrate.
نویسندگان
چکیده
Total synthesis of ceratopicanol (1) was achieved with a tandem cycloaddition reaction of allenyl diazo compound 6 via a trimethylenemethane (TMM) diyl intermediate. The TMM diyl mediated [2+3] cycloaddition reaction furnished the consecutive quaternary carbon centers and showed an unusual diastereoselectivity.
منابع مشابه
Total synthesis of (-)-crinipellin A.
The first total synthesis of (-)-crinipellin A is described. The tetraquinane core skeleton of crinipellin A was assembled through the tandem [2 + 3] cycloaddition reaction of an allenyl diazo substrate containing a cyclopentane ring in a single operation. The absolute stereochemistry was confirmed through the total synthesis.
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ورودعنوان ژورنال:
- Chemistry, an Asian journal
دوره 7 10 شماره
صفحات -
تاریخ انتشار 2012