Lipopolysaccharides (LPS) Pathways of Complement by Bacterial Activation of the Classical and Properdin
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منابع مشابه
MACROPHAGE STIMULATION BY BACTERIAL LIPOPOLYSACCHARIDES II. Evidence for Differentiation Signals Delivered by Lipid A and by a Protein Rich Fraction of Lipopolysaccharides* BY WILLIAM F. DOE,$ SOU
Bacterial lipopolysaccharides (LPS) I stimulate mouse peritoneal macrophages to lyse tumor target cells in vitro (1-3). The mechanisms involved in the differentiation of macrophages into killer cells can now be explored by using the model described in the accompanying paper (3). In that study, purified LPS extracted from a rough mutant of Salmonella minnesota (R595) added to confluent monolayer...
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Complement promotes the rapid recognition and elimination of pathogens, infected cells, and immune complexes. The biochemical basis for its target specificity is incompletely understood. In this report, we demonstrate that properdin can directly bind to microbial targets and provide a platform for the in situ assembly and function of the alternative pathway C3 convertases. This mechanism differ...
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The complement system may be activated by at least two different pathways: the clinical pathway involving C1, C4 and C2 and the alternative pathway involving properdin, C3, factor B and factor D. The classical pathway can be activated by antigen antibody complexes, while the alternative pathway can be activated by other substances such as natural polysaccharides. Both pathways lead to an activ...
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Levels of components of the classical and alternative complement pathways and the activity of the C3 nephritic factor (C3NeF) were measured in serum specimens from patients with type I (subendothelial deposits) and type II (intramembranous dense deposits) membranoproliferative glomerulonephritis (MPGN) and the results compared with the levels in normal subjects. Although C3 and C5 concentration...
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An immunochemical and functional analysis of the classical and alternate complement pathways in human serum was performed in the presence of 10 mM ethylene glycol tetraacetic acid (EGTA) and MgCl(2)-EGTA (MgEGTA), chelating agents which have been recently utilized as a means of distinguishing between these two complement pathways. Total hemolytic activity, integrity of the C1 complex, hemolytic...
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