Efficient asymmetric organocatalytic formation of erythrose and threose under aqueous conditions.

نویسندگان

  • Laurence Burroughs
  • Matthew E Vale
  • James A R Gilks
  • Henrietta Forintos
  • Christopher J Hayes
  • Paul A Clarke
چکیده

Esters of proteinogenic amino acids efficiently catalyse the formation of erythrose and threose under aqueous conditions in the highest yields and enantioselectivities yet reported. Remarkably while esters of (L)-proline yield (L)-carbohydrates, esters of (L)-leucine and (L)-alanine generate (D)-carbohydrates, offering the potential to account for the prebiotic link between natural (L)-amino acids and natural (D)-sugars.

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عنوان ژورنال:
  • Chemical communications

دوره 46 26  شماره 

صفحات  -

تاریخ انتشار 2010