MYELOID NEOPLASIA Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia
نویسندگان
چکیده
1Institut Cochin, Université Paris Descartes, Centre National de la Recherche Scientifique (CNRS, UMR8104), Paris; 2Inserm U567, Paris; 3Service de Médecine Interne-UF d’Hématologie, Assistance Publique-Hopitaux de Paris (AP-HP), 4Service d’Hématologie Biologique, APHP, Hôpital Cochin, Paris; 5Service d’hématologie, Hôpital de la Pitié-Salpêtrière, Paris; and 6Service des Maladies du Sang, Centre Hospitalier Universitaire (CHU) Angers, France
منابع مشابه
Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia.
The deregulation of translation markedly contributes to the malignant phenotype in cancers, and the assembly of the translation initiating complex eIF4F is the limiting step of this process. The mammalian Target of Rapamycin Complex 1 (mTORC1) is thought to positively regulate eIF4F assembly and subsequent oncogenic protein synthesis through 4E-BP1 phosphorylation. We showed here that the trans...
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