Susceptibility of Ceftolozane-Tazobactam and Ceftazidime-Avibactam Against a Collection of β-Lactam-Resistant Gram-Negative Bacteria
نویسندگان
چکیده
Mark D. Gonzalez, Ph.D., Allison R. McMullen, Ph.D., Meghan A. Wallace, B.S., Matthew P. Crotty, Pharm.D., David J. Ritchie, Pharm.D., and Carey-Ann D. Burnham, Ph.D. Department of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, MO; Department of Laboratory Medicine, Children’s Healthcare of Atlanta, Atlanta, GA; Pharmacy Department, Barnes-Jewish Hospital, St. Louis, MO; Department of Pharmacy, Methodist Dallas Medical Center, Dallas, TX; Pharmacy Practice Department, St. Louis College of Pharmacy, St. Louis, MO, USA
منابع مشابه
Persistent Bacteremia from Pseudomonas aeruginosa with In Vitro Resistance to the Novel Antibiotics Ceftolozane-Tazobactam and Ceftazidime-Avibactam
Ceftazidime-avibactam and ceftolozane-tazobactam are new antimicrobials with activity against multidrug-resistant Pseudomonas aeruginosa. We present the first case of persistent P. aeruginosa bacteremia with in vitro resistance to these novel antimicrobials. A 68-year-old man with newly diagnosed follicular lymphoma was admitted to the medical intensive care unit for sepsis and right lower extr...
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We compared ceftazidime-avibactam, ceftolozane-tazobactam, ceftazidime, cefepime, and piperacillin-tazobactam MICs for 38 meropenem-resistant Pseudomonas aeruginosa isolates. No isolates harbored carbapenemases; 74% were oprD mutants. Ceftazidime-avibactam and ceftolozane-tazobactam were active against 92% of the isolates, including 80% that were resistant to all three β-lactams. Forty-three pe...
متن کاملCeftazidime-Avibactam Activity against Aerobic Gram Negative Organisms Isolated from Intra-Abdominal Infections in United States Hospitals, 2012-2014.
BACKGROUND Ceftazidime-avibactam is ceftazidime combined with the novel non-β-lactam β-lactamase inhibitor avibactam, which inhibits Ambler class A (e.g., extended-spectrum β-lactamase [ESBL] and KPC), class C, and some class D enzymes. We evaluated the activity of ceftazidime-avibactam against aerobic gram negative bacteria causing intra-abdominal infections (IAI). METHODS A total of 1,540 i...
متن کاملCeftolozane/tazobactam and ceftazidime/avibactam for the treatment of complicated intra-abdominal infections
INTRODUCTION The treatment of complicated intra-abdominal infections (cIAI) is increasingly challenging due to increased resistance of Gram-negative organisms. These multidrug resistant organisms lead to an increase in morbidity and mortality. This has led to renewed interest in use of older β-lactam antibiotics in combination with newer β-lactamase inhibitors. Ceftazidime-avibactam is one of t...
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