Angiogenesis and Ck19 Expression in Papillary Thyroid Carcinoma
نویسندگان
چکیده
Purpose: Aim of the present study is to evaluate immunohistochemically the diagnostic value of CK19 in papillary thyroid carcinoma (PC) and to determine the microvascular density (MDV) in tumor tissue
منابع مشابه
Expression of cytokeratin 19 in the cytosolic fraction of thyroid lesions: ELISA and Western blot analysis.
Cytokeratin 19 (CK19) is one of the most frequently studied immunohistochemical markers in thyroid pathology. The results of several studies suggest that CK19 may be useful in the diagnosis of papillary carcinoma, where it has been shown to have strong diffuse cytoplasmic reactivity. However, the published results vary, and the utility of CK19 in the diagnosis of thyroid lesions is controversia...
متن کاملDiagnostic significance of CK19, RET, galectin-3 and HBME-1 expression for papillary thyroid carcinoma.
AIMS To evaluate CK19, RET, galectin-3 and HBME-1 expression in papillary thyroid carcinoma (PTC) and to evaluate their diagnostic significance. METHODS 155 PTC specimens and 83 other diseased-thyroid specimens were collected. Immunohistochemistry for CK19, RET, galectin-3 and HBME-1 was performed. RESULTS The 155 PTC cases were classified into eight variants according to the WHO classifica...
متن کاملHBME-1 and CK19 are highly discriminatory in the cytological diagnosis of papillary thyroid carcinoma.
The cytologic diagnosis of papillary thyroid carcinoma is straightforward in most instances. However, there are some mimics including goitrous nodules and Hurthle cell neoplasms. Many studies have shown the combination of HBME-1 and CK19 expression to be useful in reaching a correct histologic diagnosis on tissue sections. We aim to assess the value of these markers in the setting of cell block...
متن کاملDiagnostic significance of CK19, TG, Ki67 and galectin-3 expression for papillary thyroid carcinoma in the northeastern region of China
BACKGROUND To evaluate the expression and differential diagnostic significance of CK19, TG, Ki67 and galectin-3 in papillary thyroid carcinoma (PTC) (metastatic and non metastatic), follicular adenoma and nodular goiter in patients from the northeastern part of China. METHODS 441 PTC specimens and 151 other benign thyroid specimens (97 cases of nodular goiter, 54 cases of nonmalignant follicu...
متن کاملStudy of correlation between vascular endothelial growth factor receptor and some prognostic factors in papillary carcinoma of thyroid gland
Background and Objective: Thyroid cancer is the most frequent endocrine malignancy in the world and papillary carcinoma is the most frequent thyroid carcinoma. Different markers used for determination of prognosis and VEGFR is one of them. The aim of present study was to determine the expression of Vascular Endothelial Growth Factor Receptor (VEGFR) as a prognostic marker in papillary carcinoma...
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