Progestogen-only Injectable Contraceptives

Depo-Provera® is depot medroxyprogesterone acetate (DMPA) aqueous suspension 150 mg in 1 ml formulated for deep IM injection. [2] This is most commonly used. Sayana Press® is DMPA 104 mg in 0.65 ml formulated for SC injection first licensed in the UK in 2011. [3] It is bio-equivalent to Depo-Provera®. It may be preferable to Depo-Provera® in women on anticoagulants or with a bleeding disorder. In women who are very obese it may be preferable if there are concerns about being able to administer an IM injection effectively. Self-administration has been studied and found to be feasible and acceptable and it was licensed for this in 2015. [4] Noristerat® is norethisterone enantate (oenanthate) 200 mg in 1 ml in an oily liquid. [5] This is only licensed for short-term use eg, for women whose partners have undergone vasectomy, until the vasectomy is effective, and after rubella immunisation.