Life Extension by Anti-Aging Drugs: Hormetic Explanation?
نویسنده
چکیده
A number of chemicals including antioxidants, vitamins and hormones are widely advertised as anti-aging drugs (geroprotectors). It is usually believed that life-extending capacity of geroprotectors may be attributed to their specific anti-aging mechanisms, even without solid scientific evidence. The analysis of the survival data gathered by both anti-aging and hormetic interventions demonstrates that many essential similarities exist between them. The evidence that life-extending effects of anti-aging drugs may be due to hormetic-like response is discussed in this review.
منابع مشابه
Epigenetic engineering and its possible role in anti-aging intervention.
Recently a cluster of new hypotheses of aging has been suggested, which explicitly predict the importance of early-life events in health and life span modulations. It has been widely assumed that these long-lasting consequences of early-life exposures may depend on the same mechanisms as those underlying "cellular memory," that is, epigenetic inheritance systems. There is a growing body of evid...
متن کاملAging-modulating treatments: from reductionism to a system-oriented perspective
The delay of aging and healthy life extension is a primary concern of modern gerontological research. Based on theoretical assumptions and empirical findings, a number of bioactive agents have been proposed as promising “anti-aging” (geroprotective) preparations (de Magalhães et al., 2012; Kennedy and Pennypacker, 2014). Usually, the substance is considered to have aging-modulating activity if ...
متن کاملRole of hormesis in life extension by caloric restriction.
Caloric restriction (CR) markedly extends the life of rats, mice and several other species, and it also modulates age-associated physiological deterioration and delays the occurrence and/or slows progression of age-associated diseases. The level of CR that retards the aging processes is a low-intensity stressor, which enhances the ability of rats and mice of all ages to cope with intense stress...
متن کاملParadigmenwechsel in der Anti-Aging-Medizin: Hormesis, Target-of-Rapamycin-Komplex und erste Anti-Aging-Pillen // Paradigm Shift in Anti-Aging Medicine: Hormesis, Target of Rapamycin Complex and First Human Anti-Aging-Pills
Paradigm Shift in Anti-Aging Medicine: Hormesis, Target of Rapamycin Complex and First Human Anti-Aging Pills. Studies in model organisms have shown that some drugs and lifestyle practices (calorie-restricted diets, regular exercise, e.g.) can extend life and health span and protect against the onset of age-related chronic diseases by targeting physiological pathways. A common mode of action wa...
متن کاملSlowing down aging from within: mechanistic aspects of anti-aging hormetic effects of mild heat stress on human cells.
Since aging is primarily the result of a failure of maintenance and repair mechanisms, various approaches are being developed in order to stimulate these pathways and modulate the process of aging. One such approach, termed hormesis, involves challenging cells and organisms by mild stress that often results in anti-aging and life prolonging effects. In a series of experimental studies, we have ...
متن کامل