Rapidly progressive obstructive jaundice due to Congo red negative amyloidosis.
نویسندگان
چکیده
Hepatic involvement in amyloidosis is common but obstructive jaundice is a very rare complication. Occasional patients with AL amyloidosis develop obstructive jaundice as a consequence of severe intrahepatic cholestasis, but review of the English literature reveals only 23 such cases. We report a further case of obstructive jaundice due to amyloidosis in which the diagnosis was particularly difficult to establish because the amyloid material was Congo red negative.
منابع مشابه
Primary amyloidosis and severe intrahepatic cholestatic jaundice.
Liver involvement in systemic amyloidosis is frequent but is rarely of clinical importance. Five patients with severe cholestatic jaundice are described and an additional 20 from published reports are reviewed. The most frequent presenting symptoms were lethargy and abdominal pain, which were present for a median of 11 months before the onset of jaundice. Hepatomegaly, usually marked, was prese...
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OBJECTIVE Systemic amyloidosis is a rare disorder, characterized by extracellular accumulation of Congo red positive fibrillar amyloid protein deposits that have an amorphous, eosinophilic appearance on hematoxylin-eosin stained preparations. The kidney is the most commonly affected organ by systemic amyloidosis. Congo red staining increases the positive birefringence of the weakly birefringent...
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BACKGROUND Detection of amyloid can be done by several techniques either histochemical or immunohistochemical. Among them, one of the less mentioned in texts of reference and in reports on amyloidosis, is the examination with ultraviolet light of the stain of Congo red. We intend to examine cases of amyloidosis stained with Congo red with ultraviolet light and to see if such method offers advan...
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عنوان ژورنال:
- The Ulster Medical Journal
دوره 60 شماره
صفحات -
تاریخ انتشار 1991