Constraints on the CD8 T cell response in chronic HBV infection
نویسنده
چکیده
.............................................................................................................. 3 Acknowledgements ........................................................................................... 14 List of common abbreviations ......................................................................... 15 Layout of Thesis ................................................................................................ 18
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Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control HBV infection.
HBV-specific CD8(+) T cells are critical for a successful immune response to HBV infection. They are markedly diminished in number in patients who fail to control the virus, but the mechanisms resulting in their depletion remain ill defined. Here, we dissected the defective HBV-specific CD8(+) T cell response associated with chronic HBV infection by gene expression profiling. We found that HBV-...
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