Hepatocyte Nucear Factor (hnf)-4α Induces Transdifferentiation of Hematopoietic Cells into Hepatocytes
نویسندگان
چکیده
Satish Khurana, Amit K Jaiswal and Asok Mukhopadhyay Stem Cell Biology Laboratory From National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi-110067, India. Current address: Stem Cell Institute, Katholieke University, Leuven, Belgium. Running head: HNF4α in hepatic differentiation Address correspondence to: Asok Mukhopadhyay, Ph.D., Stem Cell Biology Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi-110067, India. Phone: 9111-26703781; Fax: 91-11-26702125; E-mail: [email protected]
منابع مشابه
Expression of hepatocytic- and biliary-specific transcription factors in regenerating bile ducts during hepatocyte-to-biliary epithelial cell transdifferentiation
BACKGROUND Under compromised biliary regeneration, transdifferentiation of hepatocytes into biliary epithelial cells (BEC) has been previously observed in rats, upon exposure to BEC-specific toxicant methylene dianiline (DAPM) followed by bile duct ligation (BDL), and in patients with chronic biliary liver disease. However, mechanisms promoting such transdifferentiation are not fully understood...
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