Enteroviruses 2 Apro targets MDA 5 and MAVS in infected cells
نویسندگان
چکیده
6 Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary 7 Medicine, Utrecht University, Utrecht, 3584 CL, The Netherlands 8 Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, 9 Nijmegen, 6525 GA, The Netherlands 10 Department of Human and Molecular Genetics, VCU Institute of Molecular Medicine, VCU 11 Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, 12 Virginia, VA 23298, USA 13 Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, 14 TX 77584, USA 15 Current address: department of Tumor Immunology, Radboud University Nijmegen Medical 16 Centre, Nijmegen, 6525 GA, The Netherlands 17
منابع مشابه
Enterovirus 2Apro targets MDA5 and MAVS in infected cells.
UNLABELLED RIG-I-like receptors (RLRs) MDA5 and RIG-I are key players in the innate antiviral response. Upon recognition of viral RNA, they interact with MAVS, eventually inducing type I interferon production. The interferon induction pathway is commonly targeted by viruses. How enteroviruses suppress interferon production is incompletely understood. MDA5 has been suggested to undergo caspase- ...
متن کاملEnterovirus 2A Targets MDA5 and MAVS in Infected Cells
RIG-I-like receptors (RLRs) MDA5 and RIG-I are key players in the innate antiviral response. Upon recognition of viral RNA, they interact with MAVS, eventually inducing type I interferon production. The interferon induction pathway is commonly targeted by viruses. How enteroviruses suppress interferon production is incompletely understood. MDA5 has been suggested to undergo caspaseand proteasom...
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In mouse embryonic fibroblasts (MEFs), the bovine rotavirus (UK strain) but not the simian rhesus rotavirus (RRV) robustly triggers beta interferon (IFN-β) secretion, resulting in an IFN-dependent restriction of replication. We now find that both rotavirus strains trigger antiviral transcriptional responses early during infection and that both transcriptional responses and IFN-β secretion are c...
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Coxsackie B viruses (CVB) are enteroviruses that have been associated with a variety of human diseases, including myocarditis. In the present study, we found that MDA5 and its adaptor molecule MAVS are critical for type I interferon responses to CVB, since the absence of either MAVS or MDA5 leads to deficient type I interferon production and early mortality in mice infected with CVB. Pancreatic...
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تاریخ انتشار 2014