Non-equilibrium fluctuations of a semi-flexible filament driven by active cross-linkers
نویسندگان
چکیده
Ines Weber, 2 Cécile Appert-Rolland, Grégory Schehr, and Ludger Santen Fachrichtung Theoretische Physik, Universität des Saarlandes D-66123 Saarbrücken, Germany Laboratoire de Physique Théorique, CNRS (UMR 8627), Univ. Paris-Sud, Univ. Paris-Saclay, 91405 Orsay, France Laboratoire de Physique Théorique et Modèles Statistiques, CNRS (UMR 8626), Univ. Paris-Sud, Univ. Paris-Saclay, 91405 Orsay, France (Dated: September 5, 2016)
منابع مشابه
MEDYAN: Mechanochemical Simulations of Contraction and Polarity Alignment in Actomyosin Networks
Active matter systems, and in particular the cell cytoskeleton, exhibit complex mechanochemical dynamics that are still not well understood. While prior computational models of cytoskeletal dynamics have lead to many conceptual insights, an important niche still needs to be filled with a high-resolution structural modeling framework, which includes a minimally-complete set of cytoskeletal chemi...
متن کاملStochastic Ratcheting on a Funneled Energy Landscape is Necessary for Highly Efficient Contractility of Actomyosin Force Dipoles
Current understanding of how contractility emerges in disordered actomyosin networks of nonmuscle cells is still largely based on the intuition derived from earlier works on muscle contractility. In addition, in disordered networks, passive cross-linkers have been hypothesized to percolate force chains in the network, hence, establishing large-scale connectivity between local contractile cluste...
متن کاملSpontaneous flow transition in active polar gels
– We study theoretically the effects of confinement on active polar gels such as the actin network of eukaryotic cells. Using generalized hydrodynamics equations derived for active gels, we predict, in the case of quasi one-dimensional geometry, a spontaneous flow transition from a homogeneously polarized immobile state for small thicknesses, to a perturbed flowing state for larger thicknesses....
متن کاملPersistence of strain in motor-filament assemblies
Crosslinked semi-flexible and flexible filaments that are actively deformed by molecular motors occur in various natural settings, such as the ordered eukaryotic flagellum, and the disordered cytoskeleton. The deformation of these composite systems is driven by active motor forces and resisted by passive filament elasticity, and structural constraints due to permanent cross-links. Using a mean ...
متن کاملNonlinear elasticity of stiff biopolymers connected by flexible linkers.
Networks of the biopolymer actin, cross-linked by the compliant protein filamin, form soft gels. They can, however, withstand large shear stresses due to their pronounced nonlinear elastic behavior. The nonlinear elasticity can be controlled by varying the number of cross-links per actin filament. We propose and test a model of rigid filaments decorated by multiple flexible linkers that is in q...
متن کامل