A 1 2 3 4 5 6 7 8 9 1 0 1 1 m 1500

نویسندگان

  • Norihiro Iwamoto
  • Tatsuya Kawaguchi
  • Kentaro Horikawa
  • Shoichi Nagakura
  • Tadashi Kagimoto
  • Toshio Suda
  • Kiyoshi Takatsuki
  • Hideki Nakakuma
چکیده

In paroxysmal nocturnal hemoglobinuria (PNH), little is known about the molecular events leading to the clinical manifestations except for the hemolysis. To unfold the complex pathophysiology, it is necessary to elucidate the nature of the PNH clone. PNH exhibits an acquired stem cell disorder, a clonal expansion of affected cells, concomitant depression of normal hematopoiesis in bone marrow (BM), and, although infrequently, the development of leukemia. The PNH clone is thus expected to exhibit some neoplastic features. We report here that CD34+ hematopoietic progenitor cells of PNH-BM yielded blood cells of three lineages with

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تاریخ انتشار 2002