Chemical leukoderma induced by dimethyl sulfate*
نویسندگان
چکیده
Chemical leukoderma occurs due to the toxic effect of a variety of chemical agents. Mechanisms include either destruction or inhibition of melanocytes. We report two male patients (36 and 51 years old) who presented with multiple hypopigmented macules and patches on the neck, wrist, and legs after exposure to dimethyl sulfate in a chemical industry. Physical examination revealed irregular depigmentation macules with sharp edges and clear hyperpigmentation around the lesions. History of repeated exposure to a chemical agent can help the clinical diagnosis of chemical leukoderma. This diagnosis is very important for prognosis and therapeutic management of the disease.
منابع مشابه
Chemical Leukoderma Improved by Low-dose Steroid Pulse Therapy.
Chemical leukoderma occurs due to the toxic effect of a specific chemical preceding allergic contact dermatitis. The mechanism is either destruction or inhibition of melanocytes by the offending substance. Clinicohistopathologically, no absolute criteria can differentiate chemical leukoderma from vitiligo. However, chemical leukoderma can be diagnosed clinically by a history of repeated exposur...
متن کاملChemical Leukoderma to Hair Dye in a Singaporean Indian – A Rare, Adverse Cosmetic Outcome in Relation to a Ubiquitous Cosmetic Product
Chemical Leukoderma is a rare phenomenon in our local Singapore population. The simultaneous occurrence of both hypopigmentation and hyperpigmentation in our patient, which represents development of Chemical Leukoderma (melanocytic inhibitory reaction) and postinflammatory hyperpigmentation (melanocytic stimulatory reaction) respectively, is presumptively even rarer. Plausible underlying pathop...
متن کاملIn Vitro Methods for Predicting Chemical Leukoderma Caused by Quasi-Drug Cosmetics
Skin care cosmetics frequently contain whitening or lightening agents. The present study aimed to establish in vitro methods for predicting chemical leukoderma caused by whitening agents in cosmetics. The risks of chemical leukoderma were predicted based on percutaneous absorption rates, toxic concentrations, and toxicity mechanisms. Thus, in vitro skin permeation rate and cytotoxic concentrati...
متن کاملLack of chemically induced mutation in repair-deficient mutants of yeast.
Two genes, rad6 and rad9, that confer radiation sensitivity in the yeast Saccharomyces cerevisiae also greatly reduce the frequency of chemically-induced reversions of a tester mutant cyc1-131, which is a chain initiation mutant in the structural gene determining iso-1-cytochrome c. Mutations induced by ethyl methanesulfonate (EMS), diethyl sulfate (DES), methyl methanesulfonate (MMS), dimethyl...
متن کاملA possible chemical explanation for the events associated with the death of Gloria Ramirez at Riverside General Hospital.
The events associated with the death of Gloria Ramirez at Riverside General Hospital on 19 February 1994 have been portrayed as a major medical mystery. A potential chemical explanation for this incident has been developed. The hypothetical scenario depends upon the oxidation of a common solvent, dimethyl sulfoxide, through dimethyl sulfone to dimethyl sulfate. The latter compound is a volatile...
متن کامل