Hypertrophy Induced by Pressure Overload Inhibition of mTOR Signaling With Rapamycin Regresses Established Cardiac
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چکیده
Julie R. McMullen, Megan C. Sherwood, Oleg Tarnavski, Li Zhang, Adam L. Dorfman, Tetsuo Hypertrophy Induced by Pressure Overload Inhibition of mTOR Signaling With Rapamycin Regresses Established Cardiac Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2004 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.0000130641.08705.45 2004;109:3050-3055; originally published online June 7, 2004; Circulation. http://circ.ahajournals.org/content/109/24/3050 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload.
BACKGROUND Rapamycin is a specific inhibitor of the mammalian target of rapamycin (mTOR). We recently reported that administration of rapamycin before exposure to ascending aortic constriction significantly attenuated the load-induced increase in heart weight by approximately 70%. METHODS AND RESULTS To examine whether rapamycin can regress established cardiac hypertrophy, mice were subjected...
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Previous studies have suggested that inhibition of the mammalian target of rapamycin (mTOR) by rapamycin suppresses myocardial hypertrophy. However, the role of mTOR in the progression of cardiac dysfunction in pathological hypertrophy has not been fully defined. Interestingly, recent reports indicate that the inflammatory response, which plays an important role in the development of heart fail...
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BACKGROUND Cardiac hypertrophy, or an increase in heart size, is an important risk factor for cardiac morbidity and mortality. The mammalian target of rapamycin (mTOR) is a component of the insulin-phosphoinositide 3-kinase pathway, which is known to play a critical role in the determination of cell, organ, and body size. METHODS AND RESULTS To examine the role of mTOR in load-induced cardiac...
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Growing evidence shows that protein kinase D (PKD) plays an important role in the development of pressure overload-induced cardiac hypertrophy. However, the mechanisms involved are not clear. This study tested our hypothesis that PKD might mediate cardiac hypertrophy by negatively regulating autophagy using the technique of PKD knockdown by siRNA. Cardiac hypertrophy was induced in 8-week old m...
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The heart has two major modalities of hypertrophy in response to hemodynamic loads: concentric and eccentric hypertrophy caused by pressure and volume overload (VO), respectively. However, the molecular mechanism of eccentric hypertrophy remains poorly understood. Here we demonstrate that the Akt-mammalian target of rapamycin (mTOR) axis is a pivotal regulator of eccentric hypertrophy during VO...
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