Physical and Functional Interaction between DOM-B and ACF1 The Interception of Two Distinct Nucleosome Remodeling Principles
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منابع مشابه
Splice variants of the SWR1-type nucleosome remodeling factor Domino have distinct functions during Drosophila melanogaster oogenesis.
SWR1-type nucleosome remodeling factors replace histone H2A by variants to endow chromatin locally with specialized functionality. In Drosophila melanogaster a single H2A variant, H2A.V, combines functions of mammalian H2A.Z and H2A.X in transcription regulation and the DNA damage response. A major role in H2A.V incorporation for the only SWR1-like enzyme in flies, Domino, is assumed but not we...
متن کاملOpposing ISWI- and CHD-class chromatin remodeling activities orchestrate heterochromatic DNA repair
Heterochromatin is a barrier to DNA repair that correlates strongly with elevated somatic mutation in cancer. CHD class II nucleosome remodeling activity (specifically CHD3.1) retained by KAP-1 increases heterochromatin compaction and impedes DNA double-strand break (DSB) repair requiring Artemis. This obstruction is alleviated by chromatin relaxation via ATM-dependent KAP-1S824 phosphorylation...
متن کاملSplice Variants of the SWR1-type Nucleosome Remodeling Factor Domino Have
24 SWR1-type nucleosome remodeling factors replace histone H2A by variants to endow chromatin lo25 cally with specialized functionality. In Drosophila melanogaster a single H2A variant, H2A.V, com26 bines functions of mammalian H2A.Z and H2A.X in transcription regulation and DNA damage re27 sponse. A major role in H2A.V incorporation for the only SWR1-like enzyme in flies, Domino, is 28 assumed...
متن کاملBinding of Acf1 to DNA involves a WAC motif and is important for ACF-mediated chromatin assembly.
ACF is a chromatin-remodeling complex that catalyzes the ATP-dependent assembly of periodic nucleosome arrays. This reaction utilizes the energy of ATP hydrolysis by ISWI, the smaller of the two subunits of ACF. Acf1, the large subunit of ACF, is essential for the full activity of the complex. We performed a systematic mutational analysis of Acf1 to elucidate the functions of specific subregion...
متن کاملDistinct Functions during Drosophila melanogaster Oogenesis
24 SWR1-type nucleosome remodeling factors replace histone H2A by variants to endow chromatin lo25 cally with specialized functionality. In Drosophila melanogaster a single H2A variant, H2A.V, com26 bines functions of mammalian H2A.Z and H2A.X in transcription regulation and DNA damage re27 sponse. A major role in H2A.V incorporation for the only SWR1-like enzyme in flies, Domino, is 28 assumed...
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تاریخ انتشار 2011