Leydig Cells and Sertoli Cells — Sex Cord-Stromal Tumor of the Testis
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Expression of galectin-3 in gonads and gonadal sex cord stromal and germ cell tumors.
Galectin-3, a beta-galactoside-binding lectin, has been implicated in many human malignancies, but has seldom been studied in human gonads and gonadal tumors. The aim of our study was to investigate galectin-3 mRNA and protein expression in normal ovaries and testes as well as in a variety of 51 gonadal sex cord stromal and germ cell tumors, and two testicular seminomatous and non-seminomatous ...
متن کاملRetiform Sertoli-Leydig Cell Tumor in a 38-Year-Old Woman: A Case Report, Retrospective Review, and Review of Current Literature
Ovarian sex cord-stromal tumors arise from the stromal cells that surround and support the oocytes. Sertoli-Leydig cell tumors belong to this category of ovarian neoplasms. We present the case of a 38-year-old woman who was found to have a right ovarian mass. The mass was resected and diagnosed as Stage I Sertoli-Leydig cell tumor, retiform variant, following histopathologic and immunohistochem...
متن کاملIdentification of the estrogen receptor GPER in neoplastic and non-neoplastic human testes
BACKGROUND Estrogen signaling is mediated by estrogen receptor beta isoforms in normal and neoplastic human testes. Recently, a G-protein-coupled-receptor (GPER) has been suggested as being involved in rapid responses to estrogens in different normal and tumor cells. METHODS This study investigated the GPER expression in paraffin-embedded samples from non neoplastic and neoplastic human teste...
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Testicular cancer is cancer that develops in the testicles, a part of the male reproductive system. Although testicular cancer can be derived from any cell type found in the testicles, more than 95% of testicular cancers are germ cell tumors. Most of the remaining 5% are sex cord-gonadal stromal tumors derived from Leydig cells or Sertoli cells. Over man's lifetime, his risk of testicular cance...
متن کاملTesticular cancer
Testicular cancer is cancer that develops in the testicles, a part of the male reproductive system. Although testicular cancer can be derived from any cell type found in the testicles, more than 95% of testicular cancers are germ cell tumors. Most of the remaining 5% are sex cord-gonadal stromal tumors derived from Leydig cells or Sertoli cells. Over man's lifetime, his risk of testicular cance...
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