TLR8-dependent TNF- overexpression in Fanconi anemia group C cells
نویسندگان
چکیده
1Department of Biochemistry and Molecular Biology, Oregon Health & Science University, Portland; 2Department of Pediatric Hematology/Oncology, Ospedale Gaslini, Genoa, Italy; Departments of 3Molecular and Medical Genetics and 4Medicine, Oregon Health & Science University, Portland; 5NW Veterans Affairs (VA) Cancer Research Center, Portland VA Medical Center, OR; 6Department of Physiology and Pharmacology, Oregon Health & Science University, Portland; 7Knight Cancer Institute at Oregon Health & Science University, Portland; 8Department of Molecular Biology, University of Oregon, Eugene; 9Department of Pediatrics, Oregon Health & Science University, Portland; and 10Bone Marrow Transplantation Service, Federal University of Parana, Curitiba, Brazil
منابع مشابه
FANCA and FANCC modulate TLR and p38 MAPK-dependent expression of IL-1β in macrophages.
Hematopoietic stem and progenitor cells with inactivated Fanconi anemia (FA) genes, FANCA and FANCC, are hypersensitive to inflammatory cytokines. One of these, tumor necrosis factor α (TNF-α), is also overproduced by FA mononuclear phagocytes in response to certain Toll-like receptor (TLR) agonists, creating an autoinhibitory loop that may contribute to the pathogenesis of progressive bone mar...
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