Pleiotropic effects of the HMG-CoA reductase inhibitors
نویسندگان
چکیده
The HMG-CoA reductase inhibitors (statins) are used extensively in the treatment of hyperlipidemia. They have also demonstrated a benefit in a variety of other disease processes. These secondary actions are known as pleiotropic effects. Our paper serves as a focused and updated discussion on the pleiotropy of statins and emphasizes the importance of randomized placebo-controlled trials to further elucidate this interesting phenomenon.
منابع مشابه
Clinical significance of statin pleiotropic effects: hypotheses versus evidence.
The word “pleiotropic” usually is applied to genetics, referring to the multiple actions of a single gene. Regarding drug therapy for dyslipidemia, however, the term has become synonymous with clinical benefits beyond the effects of the drug on lipoproteins. HMG-CoA reductase inhibitors (statins), as the most widely prescribed drugs in the world, have been extensively evaluated for effects inde...
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عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2011