Regional assessment of myocardial metabolic integrity in vivo by positron-emission tomography with 11C-labeled palmitate.
نویسندگان
چکیده
S-T segment changes on exercise testing with angiographic findings in patients with prior myocardial infarction. Am J Cardiol 42: 29, 1978 12. Haskell WL: Physical activity after myocardial infarction. Am J Cardiol 33: 776, 1974 13. Paine TD, Dye LE, Roitman DI, Sheffield LT, Rackley CE, Russell RO Jr, Rogers WJ: Relation of graded exercise test findings after myocardial infarction to extent of coronary artery disease and left ventricular dysfunction. Am J Cardiol 2: 716, 1978 14. Schulze RA Jr, Strauss HW, Pitt B: Sudden death in the year following myocardial infarction. Relation to ventricular premature contractions in the late hospital phase and left ventricular ejection fraction. Am J Med 62: 192, 1977 15. Calvert A, Lown B, Gorlin R: Ventricular premature beats and anatomically defined coronary heart disease. Am J Cardiol 39: 627, 1977 16. Califr RM, Burks JM, Behar VS, Margolis JR, Wagner GS: Relationships among ventricular arrhythmias, coronary artery disease, and angiographic and electrocardiographic indicators of myocardial fibrosis. Circulation 57: 725, 1978 17. Fitzgerald JW, Houston N, DeBusk RF: Natural history of ventricular arrhythmia in postinfarction patients. Circulation 54 (suppl II): 11-10, 1976
منابع مشابه
External detection and visualization of myocardial ischemia with 11C-substrates in vitro and in vivo.
To characterize externally detectable changes in myocardial metabolism of free fatty acids (FFA) and glucose associated with ischemia, isovolumically beating rabbit hearts were perfused under conditions of selected flows with cyclotron-produced, short-lived (t1/2 - 20.4 minutes), 11C-labeled isotopes of glucose and FFA. Tension-time index decreased 83% and lactate production increased from 0.5 ...
متن کاملDetection of remote myocardial infarction in patients with positron emission transaxial tomography and intravenous 11C-palmitate.
Ischemic myocardial injury has been detected recently in isolated perfused hearts and intact experimental animals with positron-emitting 11C-palmitate and reconstructive tomography providing cross-sectional images of the heart free from superimposed activity in overlying structures. To evaluate the applicability of positron emission transaxial tomography in detecting infarction in man, 10 norma...
متن کاملQuantification of infarction in cross sections of canine myocardium in vivo with positron emission transaxial tomography and 11C-palmitate.
To assess myocardial infarction quantitatively in 15 mm thick transverse sections of the canine heart in vivo we utilized a new technique, positron emission transaxial tomography (PETT) and cyclotron-produced 11C-palmitate (11C-P) injected intravenously. Results were compared to regional myocardial creatine phosphokinase (CPK) depletion, diminished 14C-palmitate accumulation in tissue extracts,...
متن کاملCharacterization of nontransmural myocardial infarction by positron-emission tomography.
The present study was performed to determine whether positron emission tomography (PET) performed after i.v. 11C-palmitate permits detection and characterization of nontransmural myocardial infarction. PET was performed after the i.v. injection of 11C-palmitate in 10 normal subjects, 24 patients with initial nontransmural myocardial infarction (defined electrocardiographically), and 22 patients...
متن کاملLocalization of viable, ischemic myocardium by positron-emission tomography with 11C-palmitate.
Regional metabolism of exogenous fatty acid extracted by myocardium depends primarily on oxidation. Positron-emission tomography (PET) delineates necrotic myocardium by virtue of its failure to extract labeled fatty acid. In ischemic myocardium, fatty acid is extracted, but metabolized slowly. This study was performed to determine whether viable, but ischemic, tissue could be detected and local...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Circulation
دوره 61 2 شماره
صفحات -
تاریخ انتشار 1980