Identification of a glycosyltransferase from Mycobacterium marinum involved in addition of a caryophyllose moiety in lipooligosaccharides.

نویسندگان

  • Debasmita Sarkar
  • Mandeep Sidhu
  • Albel Singh
  • Jiemin Chen
  • David A Lammas
  • Astrid M van der Sar
  • Gurdyal S Besra
  • Apoorva Bhatt
چکیده

Deletion of Mycobacterium marinum MMAR2333 resulted in the loss of three of four subclasses of lipooligosaccharides (LOSs). The mutant was unable to extend an intermediate (LOS-II*) by addition of caryophyllose. These data and the predicted domain structure suggest that MMAR2333 is a glycosyltransferase involved in the generation of a lipid-linked caryophyllose donor.

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عنوان ژورنال:
  • Journal of bacteriology

دوره 193 9  شماره 

صفحات  -

تاریخ انتشار 2011