Aquaporin, Midkine and Glioblastoma

Midkine Signaling in Glioblastoma: A Novel Developmental Drug Target?

Role of aquaporin-4 in the regulation of migration and invasion of human glioma cells.

Glioblastoma is the most aggressive form of primary brain tumor with a tendency to invade surrounding healthy brain tissues, rendering tumors of this type largely incurable. Aquaporin-4 (AQP4) is a key molecule involved in maintaining water and ion homeostasis in the central nervous system and has been recently reported to play a role in cell migration in addition to its well-known function in ...

Midkine: A Promising Molecule for Drug Development to Treat Diseases of the Central Nervous System

Midkine (MK) is a heparin-binding cytokine, and promotes growth, survival, migration and other activities of target cells. After describing the general properties of MK, this review focuses on MK and MK inhibitors as therapeutics for diseases in the central nervous system. MK is strongly expressed during embryogenesis especially at the midgestation period, but is expressed only at restricted si...

Knockdown a Water Channel Protein, Aquaporin-4, Induced Glioblastoma Cell Apoptosis

Glioblastomas are the most aggressive forms of primary brain tumors due to their tendency to invade surrounding healthy brain tissues, rendering them largely incurable. The water channel protein, Aquaporin-4 (AQP4) is a key molecule for maintaining water and ion homeostasis in the central nervous system and has recently been reported with cell survival except for its well-known function in brai...

Growth responses and aquaporin expression in grape genotypes under salinity. Nayer Mohammadkhani*, Reza Heidari, Nasser Abbaspour and Fatemeh Rahmani

The effects of salinity on growth, leaf area and water relations of two grape genotypes (Gharashani and Shirazi) were studied under 2-week salinity (25, 50 and 100 mM NaCl). Growth and fresh weights of all plant parts were significantly (p