Dihydrofolate reductase inhibitory peptides screened from a structured designed β-loop peptide library displayed on phage.

نویسندگان

  • Hiroshi Tsutsumi
  • Kazuhiko Nakano
  • Hisakazu Mihara
چکیده

Enzyme inhibitory peptides with a loop structure stabilized using an antiparallel β-sheet scaffold (β-loop peptide) were obtained from a designed peptide phage library. Human dihydrofolate reductase (hDHFR) was used as the target enzyme. The obtained β-loop peptides were competitive inhibitors of hDHFR with micromolar inhibition constants and dissociation constants.

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عنوان ژورنال:
  • Molecular bioSystems

دوره 11 10  شماره 

صفحات  -

تاریخ انتشار 2015