Zinc and Skin Disorders
نویسندگان
چکیده
The skin is the third most zinc (Zn)-abundant tissue in the body. The skin consists of the epidermis, dermis, and subcutaneous tissue, and each fraction is composed of various types of cells. Firstly, we review the physiological functions of Zn and Zn transporters in these cells. Several human disorders accompanied with skin manifestations are caused by mutations or dysregulation in Zn transporters; acrodermatitis enteropathica (Zrt-, Irt-like protein (ZIP)4 in the intestinal epithelium and possibly epidermal basal keratinocytes), the spondylocheiro dysplastic form of Ehlers-Danlos syndrome (ZIP13 in the dermal fibroblasts), transient neonatal Zn deficiency (Zn transporter (ZnT)2 in the secretory vesicles of mammary glands), and epidermodysplasia verruciformis (ZnT1 in the epidermal keratinocytes). Additionally, acquired Zn deficiency is deeply involved in the development of some diseases related to nutritional deficiencies (acquired acrodermatitis enteropathica, necrolytic migratory erythema, pellagra, and biotin deficiency), alopecia, and delayed wound healing. Therefore, it is important to associate the existence of mutations or dysregulation in Zn transporters and Zn deficiency with skin manifestations.
منابع مشابه
The Role of the Slc39a Family of Zinc Transporters in Zinc Homeostasis in Skin
The first manifestations that appear under zinc deficiency are skin defects such as dermatitis, alopecia, acne, eczema, dry, and scaling skin. Several genetic disorders including acrodermatitis enteropathica (also known as Danbolt-Closs syndrome) and Brandt's syndrome are highly related to zinc deficiency. However, the zinc-related molecular mechanisms underlying normal skin development and hom...
متن کاملGreen Synthesis of Zinc Oxide Nanoparticles using Garlic skin extract and Its Characterization
Plant-mediated synthesis of metal oxide nanoparticles is a promising alternative to the traditional method of physical and chemical synthesis. In this paper, we report the green synthesis of zinc oxide nanoparticles (ZnONPs) by a biological method. During the study, Zinc oxide nanoparticles were synthesized by Allium sativum skin (garlic skin) extract. Formation of zinc oxide nanoparticles has ...
متن کاملHyperkeratotic skin conditions in New World camelids
Hyperkeratotic skin conditions in New World camelids include chronic mite infestation, zinc-responsive dermatosis, ichthyosis, and idiopathic necrolytic neutrophilic hyperkeratosis (INNH, also known as “munge”). Although these disorders are relatively uncommon, clinical signs may be severe and aesthetics may negatively impact the value of animals used for production. Hyperkeratotic lesions are ...
متن کاملThe New Progresses in Zn Requirements of Poultry
There were no considerable up to date on the trace element requirements of commercial poultry in recent years in despite of the progress in their performance traits. One of the more prevalent problems in modern broiler production system which could be attributed to the trace mineral inadequacy is skeletal disorders. Zinc, is an essential trace element which acts as a co-factor in several metalo...
متن کاملZinc Cream and Reliability of Tuberculosis Skin Testing
In 50 healthy Peruvian shantytown residents, zinc cream applied to tuberculosis skin-test sites caused a 32% increase in induration compared with placebo cream. Persons with lower plasma zinc had smaller skin-test reactions and greater augmentation with zinc cream. Zinc deficiency caused false-negative skin-test results, and topical zinc supplementation augmented antimycobacterial immune respon...
متن کاملEffects of non-toxic zinc exposure on human epidermal keratinocytes.
Zinc is an essential microelement; its importance to the skin is highlighted by the severe skin symptoms in hereditary or acquired zinc deficiency, by the improvement of several skin conditions using systemic or topical zinc preparations and by the induced intracellular zinc release upon UVB exposure, which is the main harmful environmental factor to the skin. Understanding the molecular backgr...
متن کامل