Speaker Abstracts
نویسنده
چکیده
Our understanding of brain metabolism and neuronal-astrocytic interactions are continuously changing and evolving as better tools become available for unraveling the metabolic specialization(s) and interactions of brain cells. Techniques including improved microscopy, cell isolation techniques, targeting of specific tagged/inducible genes and fluorescent proteins to specific organelles such as mitochondria in astrocytes and neurons, in vitro and vivo imaging of Ca fluxes and NADH formation in cells and brain and 13CNMR spectroscopy have provided new information and insights that have changed our understanding of brain metabolism over the past two decades. Brain energy metabolism remains an exciting, constantly changing and clinically relevant field. As investigators we must rigorously evaluate new findings and be willing to embrace new concepts when there is solid evidence that the concepts are valid for metabolism in vivo. We must also maintain a healthy skepticism regarding concepts for which the evidence is exclusively from cell culture studies and not yet demonstrated or confirmed in vivo. It is crucial to identify important areas where more studies, and perhaps different approaches, are needed to increase our knowledge and understanding of the dynamics of metabolic regulation and interand intracellular trafficking and compartmentation of metabolism in brain. Several changing concepts and areas of controversy will be presented.
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