Oral Fluid and Plasma Cannabinoid Ratios after Around-the-Clock Controlled Oral -Tetrahydrocannabinol Administration
نویسندگان
چکیده
METHODS: Ten male daily cannabis smokers received around-the-clock escalating 20-mg oral tetrahydrocannabinol (THC, dronabinol) doses (40 – 120 mg/day) for 8 days. Plasma and OF samples were simultaneously collected before, during, and after dosing. OF THC, 11-hydroxy-THC and 11-nor-9carboxy-THC (THCCOOH) were quantified by GC-MS at 0.5g/L, 0.5g/L, and 7.5-ng/L limits of quantification (LOQs), respectively. In plasma, the LOQs were 0.25 g/L for THC and THCCOOH, and 0.5 g/L for 11-hydroxy-THC.
منابع مشابه
Oral fluid and plasma cannabinoid ratios after around-the-clock controlled oral Δ(9)-tetrahydrocannabinol administration.
BACKGROUND Oral fluid (OF) testing is increasingly important for drug treatment, workplace, and drugged-driving programs. There is interest in predicting plasma or whole-blood concentrations from OF concentrations; however, the relationship between these matrices is incompletely characterized because of few controlled drug-administration studies. METHODS Ten male daily cannabis smokers receiv...
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