Mammary Gland Involution: Events, Regulation and Influences on Breast Disease
نویسندگان
چکیده
Lactation is under homeostatic control, and sustained milk stasis or weaning leads to mammary gland involution. This transition is under the control of systemic and local factors. Of all the phases of mammary gland development, involution is the least well understood. Recent epidemiological observations suggest that involution events promote breast diseases, including breast cancer. This has renewed interest in understanding involution, and its regulation. In this chapter we discuss the events occurring during mammary gland involution and the role of various systemic and local factors in regulating these events. We also briefly review about how these processes can influence the progression of breast diseases.
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