Opioid Peptide Esters and Methods of Use Cross Reference to Related Applications
نویسنده
چکیده
(54) OPIOID PEPTIDE ESTERS AND METHODS Publication Classi?cation OF USE (51) Int. Cl. (75) Inventor: Joel S. Goldberg, Hillsborough, NC A61K 38/05 (2006.01) (US) A61P 25/04 (2006.01) A61K 38/14 (2006.01) (73) Assignee: The United States Government as C07K 5/065 (2006.01) represented by the Department of C07K 9/00 (2006.01) Veterans Affairs (52) US. Cl. USPC ............ .. 514/18.4; 560/39; 548/533; 536/53; (21) Appl. No.: 13/613,736 5l4/2l.9l; 5l4/20.9; 552/544; 540/113
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Low Molecular Weight Opioid Peptide Esters Could be Developed as a New Class of Analgesics
Low molecular weight opioid peptide esters (OPE) could become a class of analgesics with different side effect profiles than current opiates. OPE may have sufficient plasma stability to cross the blood brain barrier (BBB), undergo ester hydrolysis and produce analgesia. OPE of dipeptides, tyr-pro and tyr-gly conjugated to ethanol have a structure similar to the anesthestic agent, etomidate. Bas...
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