The Gene for Familial Polyposis Coli Maps
نویسندگان
چکیده
The inherited genetic defect in adenomatous polyposis has been localized to a small region on the long arm of chromosome 5. Sixteen DNA marker loci were used to construct a linkage map ofthe chromosome. When five kindreds segregating a gene for adenomatous polyposis coli were characterized with a number of the markers, significant linkage was found between one marker and the disease gene. Linkage analysis determined the location ofthe defective gene within a primary genetic map of chromosome 5.
منابع مشابه
Familial adenomatous polyposis, diagnosis and surveillance strategies: review article
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