In vitro and in vivo comparative and competitive activity-based protein profiling of GH29 α-l-fucosidases† †Electronic supplementary information (ESI) available: Experimental part including synthesis procedures, characterization data, copies of NMR spectra of new compounds, supporting biological figures and crystallographic information. See DOI: 10.1039/c4sc03739a

نویسندگان

Jianbing Jiang

Wouter W. Kallemeijn

Daniel W. Wright

Adrianus M. C. H. van den Nieuwendijk

Veronica Coco Rohde

Elisa Colomina Folch

Hans van den Elst

Bogdan I. Florea

Saskia Scheij

Wilma E. Donker-Koopman

Marri Verhoek

Nan Li

Martin Schürmann

Daniel Mink

Rolf G. Boot

Jeroen D. C. Codée

Gijsbert A. van der Marel

Gideon J. Davies

Johannes M. F. G. Aerts

Herman S. Overkleeft

چکیده

Jianbing Jiang, Wouter W. Kallemeijn, Daniel W. Wright, Adrianus M. C. H. van den Nieuwendijk, Veronica Coco Rohde, a Elisa Colomina Folch, a Hans van den Elst, a Bogdan I. Florea, a Saskia Scheij, b Wilma E. Donker-Koopman, b Marri Verhoek, b Nan Li, a Martin Schürmann, Daniel Mink, d Rolf G. Boot, b Jeroen D. C. Codée, a Gijsbert A. van der Marel, a Gideon J. Davies, c Johannes M. F. G. Aerts* and Herman S. Overkleeft.*

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منابع مشابه

In vitro and in vivo comparative and competitive activity-based protein profiling of GH29 α-l-fucosidases.

GH29 α-l-fucosidases catalyze the hydrolysis of α-l-fucosidic linkages. Deficiency in human lysosomal α-l-fucosidase (FUCA1) leads to the recessively inherited disorder, fucosidosis. Herein we describe the development of fucopyranose-configured cyclophellitol aziridines as activity-based probes (ABPs) for selective in vitro and in vivo labeling of GH29 α-l-fucosidases from bacteria, mice and ma...

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Racemic hemiacetals as oxygen-centered pronucleophiles triggering cascade 1,4-addition/Michael reaction through dynamic kinetic resolution under iminium catalysis. Development and mechanistic insights† †Electronic supplementary information (ESI) available: Detailed experimental procedures and characterization of all new compounds, including copies of NMR spectra and HPLC chromatograms traces, computational details and Cartesian coordinates of all stationary points. CCDC 1525188 (4l), 1525189 (6a) and 1525190 (9a). For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc00009j Click here for additional data file. Click here for additional data file.

Department of Organic Chemistry II, Unive P.O. Box 644, 48080 Bilbao, Spain Departamento de Śıntesis y Estructura de Bi y Catálisis Homogénea (ISQCH), Universida Servicio de Resonancia Magnética Nuclear, C (CEQMA), Universidad de Zaragoza, CSIC, † Electronic supplementary information procedures and characterization of all NMR spectra and HPLC chromatogram Cartesian coordinates of all stationary...

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