Ribosomal Rna in the Nucleolus Organizer
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Human autoantibody to RNA polymerase I transcription factor hUBF. Molecular identity of nucleolus organizer region autoantigen NOR-90 and ribosomal RNA transcription upstream binding factor
In dividing eukaryotic cells, nucleoli disperse before mitosis and reform in daughter cells at sites of ribosomal RNA (rRNA) gene clusters that are at the secondary constrictions of chromosomes, called nucleolus organizer regions (NORs). In this study, cDNA clones for a NOR autoantigen (NOR-90) were selected using a specific human autoantibody probe and were subsequently identified to encode an...
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The nucleus is a highly organized structure. However, unlike cytoplasmic organelles, nuclear substructures are not bounded by membranes, but rather are held together by interactions between their component proteins and nucleic acids, and are thus probably best regarded as giant, extended multimolecular complexes. The nucleolus is themost prominent of these structures. It is the site of transcri...
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