Pharmacokinetic Study of Spray Dried Paliperidone Composition in Rats
نویسنده
چکیده
The pharmacokinetics of spray dried composition (1:1 PAL: K12) and pure PAL was evaluated following oral administration (0.8 mg/kg) in healthy female Sprague Dawley rats. The extent of the mean plasma exposures of PAL was 11-fold higher in animals treated with spray dried mixture of PAL, K12 (1:1) compared to animals treated with PAL. Spray drying of PAL with Plasdones, especially Plasdone K12, reduced drug crystallinity and increased the bioavailability.
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