HBxAPα/Rsf-1-mediated HBx–hBubR1 interactions regulate the mitotic spindle checkpoint and chromosome instability Sunyoung Chae1,2, Jae-Hoon Ji2, Soon-Hwan Kwon1, Ho-Soo Lee1,2, Jung Mi Lim3, Dongmin Kang3, Chang-Woo Lee4 and Hyeseong Cho1,2,*
نویسندگان
چکیده
1Department of Biochemistry and Molecular Biology, Ajou University School of Medicine and the Graduate School of Molecular Science and Technology, Ajou University, Suwon, South Korea, 2Genomic Instability Research Center, Ajou University School of Medicine, Suwon, South Korea, 3Department of Life Science, Division of Life and Pharmaceutical Sciences, and the Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul, South Korea and 4Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, South Korea
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p53 activation in response to mitotic spindle damage requires signaling via BubR1-mediated phosphorylation.
The mitotic spindle checkpoint plays a crucial role in regulating accurate chromosome segregation and preventing the adaptation of multiploid progeny cells. Recent reports have indicated that the induction of p53 by mitotic checkpoint activation is essential for protecting cells from abnormal chromosome ploidization caused by mitotic failure. However, although studies have shown that p53 defici...
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Accumulation of PLK1 at kinetochores is essential for chromosome alignment and segregation; however, the mechanism underlying PLK1 recruitment to kinetochores remains unresolved. The chromatin remodeller RSF1 tightly associates with centromere proteins, but its mitotic function is unknown. Here we show that RSF1 localizes at mitotic kinetochores and directly binds PLK1. RSF1 depletion disrupts ...
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