Temperature matters with rodent metabolic studies
نویسنده
چکیده
An illusory goal in obesity therapeutics is to increase energy expenditure without provoking a compensatory rise in food intake. With the (re)discovery that functional and inducible brown fat exists in adult humans, studies aimed at understanding the physiology and activation of brown adipose tissue (BAT) have proliferated. Yet, intermittent cold exposure alone is often accompanied with an increase in food intake. Cold and β-adrenergic specific agonist treatments have both been shown to activate brown fat in adult humans, suggesting the feasibility of therapeutic activation of this tissue.
منابع مشابه
Effect of gestational and postnatal environmental temperature on metabolic rate in the altricial rodent, Phyllotis darwini
1. In the altricial rodent, Phyllotis darwini, we found higher body temperatures and faster developmental rates of the thermoregulatory capacity in neonates born from coldthan warm-
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