Author's response to reviews Title: Treatment of children and adolescents with ulcerative colitis by adsorptive depletion of myeloid lineage leucocytes as monotherapy or in combination with low dose prednisolone after failure of first-line medications Authors:

نویسندگان

  • Tomotaka Tanaka
  • Shinichiro Sugiyama
  • Tsuyoshi Kajihara
  • Morihisa Akagi
  • Toshio Miura
چکیده

Regarding ethical considerations, please be advised that the medications applied in this study are all routinely used to treat patients with ulcerative colitis. All are officially approved interventions. Additionally, it is our hospital policy that all patients accept the treatment option and are treated in accord with the Helsinki Declaration as stated in the methods section, under Ethical considerations.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Treatment of children and adolescents with ulcerative colitis by adsorptive depletion of myeloid lineage leucocytes as monotherapy or in combination with low dose prednisolone after failure of first-line medications. The authors thank you for your communication

Title: Treatment of children and adolescents with ulcerative colitis by adsorptive depletion of myeloid lineage leucocytes as monotherapy or in combination with low dose prednisolone after failure of first-line medications

متن کامل

Treatment of children and adolescents with ulcerative colitis by adsorptive depletion of myeloid lineage leucocytes as monotherapy or in combination with low dose prednisolone after failure of first-line medications

BACKGROUND Currently available drugs for the treatment of ulcerative colitis (UC) include salicylates, thiopurines, corticosteroids and new anti-tumour necrosis factor (TNF)-α biologics. Among these medications, corticosteroids in children and adolescents may adversely affect the patients' growth and development. Further, UC patients have elevated and activated myeloid lineage leucocytes includ...

متن کامل

Evaluation of low doses of Azathioprine in reducing relapse and corticosteroid dependence in patients with Ulcerative Colitis

Background and Aim: Ulcerative Colitis is an idiopathic inflammatory bowel disease that is common in adults. Although corticosteroids are the most effective preservative treatment for Ulcerative Colitis. However, due to the dependence of these drugs and their serious complications, the use of an immunosuppressive drug or surgery should be taken seriously. Thus the aim of the study was the evalu...

متن کامل

Thymol has beneficial effects on the experimental model of ulcerative colitis

Objective: Thymol, a natural aromatic monoterpene phenol derived from thymus, possesses anti-inflammatory benefits. Here, we evaluated the potential of thymol therapy in improving an animal model of ulcerative colitis. Materials and Methods: Luminal instillation of acetic acid was used to induce colitis in male Wistar rats. Treatment groups daily received...

متن کامل

Is Adsorptive Granulocyte and Monocyte Apheresis Effective as an Alternative Treatment Option in Patients with Ulcerative Colitis?

Although more than one-third of patients with active ulcer-ative colitis (UC) are treated successfully using 5-aminosalicylic acid (5-ASA) as the first-line therapy, other agents such as steroids, immunosuppressants, or biologics may be used in untreated patients. 1,2 Even, in the era of biologis, approximately 25% patients remain in clinical remission and off steroids during the follow-up afte...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2013