Copper-boosting compounds: a novel concept for antimycobacterial drug discovery.
نویسندگان
چکیده
We and others recently identified copper resistance as important for virulence of Mycobacterium tuberculosis. Here, we introduce a high-throughput screening assay for agents that induce a copper hypersensitivity phenotype in M. tuberculosis and demonstrate that such copper-boosting compounds are effective against replicating and nonreplicating M. tuberculosis strains.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 57 2 شماره
صفحات -
تاریخ انتشار 2013