Effect of dose and hormones on tumor production in rats given emulsified 9, 10-dimethyl-1,2-benzanthracene intravenously.
نویسندگان
چکیده
Intravenously administered oil emulsions which contain 9,10-dimethyl-l,2-benzanthracene have been shown previously to produce a fairly high in cidence of mammary tumors in female rats (5). Male rats, however, developed few tumors, and these were chiefly papillomas arising from the se baceous gland ducts of external ears. During these and subsequent studies it became apparent that tumor incidence and dose of carcinogen were closely related, and that, at doses of 4 times the maximum previously employed, an incidence of approximately 90 per cent was achieved in 19 weeks. The simultaneous injection of hormones such as a-estradiol was also investigated because of (a) the difference noted earlier between the sexes, (6) the possibility that the endogenous supply of such hormones was not constant between female rats nor in the same female rat, and (c) the effect of such hormones on the mammary gland. The present paper deals with some of these experi ments.
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ورودعنوان ژورنال:
- Cancer research
دوره 13 7:1 شماره
صفحات -
تاریخ انتشار 1953