Association mapping of inflammatory bowel disease loci to 1 single variant resolution 2
نویسندگان
چکیده
Hailiang Huang*§, Ming Fang*, Luke Jostins*, Maša Umićević Mirkov, Gabrielle 3 Boucher, Carl A Anderson, Vibeke Andersen, Isabelle Cleynen, Adrian Cortes, 4 François Crins, Mauro D'Amato, Valérie Deffontaine, Julia Dimitrieva, Elisa 5 Docampo, Mahmoud Elansary, Kyle Kai-How Farh, Andre Franke, Ann6 Stephan Gori, Philippe Goyette, Jonas Halfvarson, Talin Haritunians, Jo Knight, 7 Ian C Lawrance, Charlie W Lees, Edouard Louis, Rob Mariman, Theo 8 Meuwissen, Myriam Mni, Yukihide Momozawa, Miles Parkes, Sarah L 9 Spain, Emilie Théâtre, Gosia Trynka, Jack Satsangi, Suzanne van Sommeren, 10 Severine Vermeire, Ramnik J Xavier, International IBD Genetics Consortium†, 11 Rinse K Weersma, Richard H Duerr, Christopher G Mathew, John D Rioux, 12 Dermot PB McGovern, Judy H Cho, Michel Georges§, Mark J Daly§, Jeffrey C 13 Barrett§ 14
منابع مشابه
Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.
BACKGROUND & AIMS Identifying shared and disease-specific susceptibility loci for Crohn's disease (CD) and ulcerative colitis (UC) would help define the biologic relationship between the inflammatory bowel diseases. More than 30 CD susceptibility loci have been identified. These represent important candidate susceptibility loci for UC. Loci discovered by the index genome scans in CD have previo...
متن کاملA Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn's Disease and Human Gut Microbiome Composition.
BACKGROUND & AIMS Genome-wide association studies have identified 200 inflammatory bowel disease (IBD) loci, but the genetic architecture of Crohn's disease (CD) and ulcerative colitis remain incompletely defined. Here, we aimed to identify novel associations between IBD and functional genetic variants using the Illumina ExomeChip (San Diego, CA). METHODS Genotyping was performed in 10,523 IB...
متن کاملThe history of genetics in inflammatory bowel disease
The influence of genetics in the etiology of inflammatory bowel disease (IBD) was initially demonstrated by epidemiological data, including differences in prevalence among different ethnic groups, familial aggregation of IBD, concordance in twins, and association with genetic syndromes. These early observations paved the way to molecular genetics in IBD, and culminated in the identification of ...
متن کاملIdentification of genomic loci controlling phenologic and morphologic traits in barley (Hordeum vulgare L.) genotypes using association analysis
Association mapping is a technique with high resolution for QTL mapping based on linkage disequilibrium and has shown more promising for describing genetically complex traits. In addition, it is a powerful tool for describing complex agronomic traits and identifying alleles that can contribute to enhance the desired traits. In this study, whole genome association mapping was used in a set of 14...
متن کاملGenetics of inflammatory bowel disease.
1. The aetiology of the chronic inflammatory bowel diseases, Crohn's disease and ulcerative colitis, is uncertain. Studies of specific environmental factors and immune dysfunction have provided little insight into disease pathogenesis. 2. Concordance rates in twin pairs and siblings provide strong evidence that genetic factors are important in disease pathogenesis. In Oxford, information was ob...
متن کاملIn-Silico Analysis of Inflammatory Bowel Disease (IBD) GWAS Loci to Novel Connections
Genome-wide association studies (GWASs) for many complex diseases, including inflammatory bowel disease (IBD), produced hundreds of disease-associated loci-the majority of which are noncoding. The number of GWAS loci is increasing very rapidly, but the process of translating single nucleotide polymorphisms (SNPs) from these loci to genomic medicine is lagging. In this study, we investigated 4,7...
متن کامل