Novel 2,5-dideoxystreptamine derivatives targeting the ribosomal decoding site RNA.
نویسندگان
چکیده
The ribosomal decoding site is the target of aminoglycoside antibiotics that specifically recognize an internal loop RNA structure. We synthesized RNA-targeted 2,5-dideoxystreptamine-4-amides in which a sugar moiety in natural aminoglycosides is replaced by heterocycles.
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ورودعنوان ژورنال:
- Bioorganic & medicinal chemistry letters
دوره 12 23 شماره
صفحات -
تاریخ انتشار 2002